《卡桑德拉大桥》是由乔治·科斯马图斯执导，理查德·哈里斯、伯特·兰卡斯特、索菲娅·罗兰等出演的灾难片。该片于1976年12月18日在意大利上映。该片讲述火车上被恐怖分子感染了致命瘟疫，车上的乘客联合起来对抗有关方面的封锁的故事 。

内容提要：三个恐怖分子奉命去炸毁“日内瓦国际卫生组织总部”大楼，被警卫发现,一个当场击毙。另二个匆忙中逃进了高度机密的实验室,都沾染上了美国政府在此秘密储存的具有高度传染性的肺鼠疫菌株。其中一个逃跑,并潜入国际列车。另一个受伤后身亡。政府当局闻讯后,命麦肯齐上校不惜一切代价,制止泄密。麦肯齐不顾国际卫生组织大夫斯屈德纳反对,命列车密封改道,开往波兰亚诺夫,企图让列车在途经年久失修的卡桑德拉大桥时，造成桥塌车毁掩人耳目。后来在乘坐这列火车的张伯伦大夫及其他旅客的奋力挽救下,终于使列车分为二截,前半截因大桥坍塌坠入河中,后半截险停断桥边。绝大部分旅客得以死里逃生。机密也终于未保住。

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